Helena, driven by the endless war she waged with her sister for the love of her mother María Helena, arrives in the world of boxing where, thanks to the enormous strength of her fists, she becomes "La Ruda". On the ring, the young promise awakens the admiration of all, in particular "La Diabla", a bloody leader of the micro-trafficking who is determined to collect a debt that does not belong to her. Helena plunges into a world of complications that lead her to distance herself from María, her sister, former boxer, and eternal rival, but her mother's precarious health forces them to meet in the ring in the “Great Fight” of their lives.